Drug Research & Approvals
Major drug-trial readouts and regulator decisions (GLP-1 era): results can re-rate a drugmaker for years in either direction, while competitors and related sectors (food, medtech) reprice.
Dated events
- · Pfizer and BioNTech report their COVID-19 vaccine was more than 90% effective in a Phase 3 interim analysis
The first interim look at the 43,538-person trial, based on 94 confirmed cases, found the vaccine more than 90% effective; the companies planned to ask the FDA for emergency use authorization. - · FDA approves Novo Nordisk's Wegovy (semaglutide 2.4 mg) for chronic weight management
It was the first once-weekly GLP-1 therapy approved for weight management; in the STEP Phase 3a trials people without type 2 diabetes lost 17-18% of their body weight on average over 68 weeks. - · Novo Nordisk's SELECT trial: semaglutide cuts major cardiovascular events by 20%
Headline results from the 17,604-person trial showed semaglutide 2.4 mg lowered the combined risk of cardiovascular death, non-fatal heart attack and non-fatal stroke by 20% versus placebo in adults with overweight or obesity and established cardiovascular disease. - · FDA approves Eli Lilly's tirzepatide as Zepbound for chronic weight management
The FDA approved Eli Lilly's tirzepatide, sold as Zepbound, for weight management in adults with obesity or overweight. The drug was already sold as Mounjaro for type 2 diabetes, so the approval let Lilly sell it for weight loss too. In trials, people on the highest dose lost about 18% of their body weight.
Assets named in this scenario · 21
AlconAstraZenecaBayerChugai PharmaceuticalDaiichi SankyoFreseniusGrifolsGSKiShares Biotechnology ETFJohnson & JohnsonLilly (Eli)LonzaMerck KGaANovartisNovo Nordisk (ADR)PfizerSanofiSiemens HealthineersSPDR S&P Biotech ETFTakeda PharmaceuticalTerumo
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